Research by Sapere
Distemperantia Allostatica Onerosus - DAO
Holbrook, Tiffanny (Project leader), Nasedkin, Val (Project leader)
Contributors
Other (2):
Demichelis, Bruno (Dr.), Litchfield, Peter (Dr.)
Description
Distemperantia Allostatica Onerosus (DAO) is proposed as a reproducible disorder of adaptive regulatory impairment arising under sustained allostatic burden, operationalized through a psychophysiological systems-regulation framework and staging model.
DAO describes maladaptive loss of adaptive regulatory capacity emerging when cumulative biologic demand exceeds the organism's ability to efficiently coordinate, integrate, recover from, and terminate adaptive responses across interacting psychophysiological systems.
DAO does not describe stress exposure itself, but the progressive impairment of the organism's capacity to dynamically regulate and recover from adaptive demand. The defining feature of DAO is not physiologic activation alone, but impaired regulation: progressive loss of psychophysiological flexibility, diminished biologic readiness, impaired recovery dynamics, reduced regulatory efficiency, and depletion of adaptive reserve despite ongoing compensatory function.
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